Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization.
Identifieur interne : 000E17 ( Main/Exploration ); précédent : 000E16; suivant : 000E18Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization.
Auteurs : Ya-Li Sang ; Wei-Ming Zhang [République populaire de Chine] ; Peng-Cheng Lv ; Hai-Liang Zhu [République populaire de Chine]Source :
- Current topics in medicinal chemistry [ 1873-4294 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Indoles.
- Humains, Polymérisation, Prolifération cellulaire, Tubuline.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Tubulin.
- chemical , pharmacology : Indoles.
- drug effects : Cell Proliferation.
- Humans, Polymerization.
Abstract
Indole is a potential lead for drug design which has been found in numerous pharmaceutically important compounds due to its medicinal properties, such as anti-tumor, anti-bacterial, anti-virus and anti-inflammatory. In the last decade, interfering with microtubule polymerization, a potential orientation to cause cell cycle arrest and apoptosis has become a promising method for cancer therapy. Thus, indole-based agents capable to modulate the microtubule assembly have gained considerable interest among scientists. This review describes the synthesis, bioactivities and SARs of indole-based agents targeting tubulin polymerization during the past decade.
DOI: 10.2174/1568026616666160530154812
PubMed: 27237326
Affiliations:
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Le document en format XML
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210046</wicri:noRegion></affiliation></author></analytic><series><title level="j">Current topics in medicinal chemistry</title><idno type="eISSN">1873-4294</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Proliferation (drug effects)</term><term>Humans</term><term>Indoles (pharmacology)</term><term>Polymerization</term><term>Tubulin (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Indoles (pharmacologie)</term><term>Polymérisation</term><term>Prolifération cellulaire ()</term><term>Tubuline ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Tubulin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Indoles</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Indoles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Polymerization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Polymérisation</term><term>Prolifération cellulaire</term><term>Tubuline</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Indole is a potential lead for drug design which has been found in numerous pharmaceutically important compounds due to its medicinal properties, such as anti-tumor, anti-bacterial, anti-virus and anti-inflammatory. In the last decade, interfering with microtubule polymerization, a potential orientation to cause cell cycle arrest and apoptosis has become a promising method for cancer therapy. Thus, indole-based agents capable to modulate the microtubule assembly have gained considerable interest among scientists. This review describes the synthesis, bioactivities and SARs of indole-based agents targeting tubulin polymerization during the past decade.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Lv, Peng Cheng" sort="Lv, Peng Cheng" uniqKey="Lv P" first="Peng-Cheng" last="Lv">Peng-Cheng Lv</name><name sortKey="Sang, Ya Li" sort="Sang, Ya Li" uniqKey="Sang Y" first="Ya-Li" last="Sang">Ya-Li Sang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Wei Ming" sort="Zhang, Wei Ming" uniqKey="Zhang W" first="Wei-Ming" last="Zhang">Wei-Ming Zhang</name></noRegion><name sortKey="Zhu, Hai Liang" sort="Zhu, Hai Liang" uniqKey="Zhu H" first="Hai-Liang" last="Zhu">Hai-Liang Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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